Thionamide-induced agranulocytosis in Graves' disease
HLA-DRB1*08:03 · rs116869525
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Who was studied 21 East Asian ancestry cases with agranulocytosis, 662 East Asian ancestry cases without agranulocytosis; replicated in 21 East Asian ancestry cases with agranulocytosis, 546 East Asian ancestry cases without agranulocytosis.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−8.
How common The T allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 13.6 kb from TSBP1-AS1.
What each result means
C/CNo copy of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Thionamide-induced agranulocytosis in Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2015 · PMID 26151496 · open access
Questions about rs116869525
What is rs116869525?
rs116869525 is a single position in the genome, in or near the HLA-DRB1*08:03 gene. Published research associates it with thionamide-induced agranulocytosis in graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs116869525 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs116869525 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116869525 come from?
GWAS Catalog, Nature communications 2015, PMID:26151496. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 514Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others4Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Thionamide-induced agranulocytosis in Graves' disease (rs116869525). MyGeneLog™. https://www.mygenelog.com/variants/rs116869525