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Standard

Total cholesterol levels

near PLB1 · rs11676985

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−10, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0136 higher (95% confidence interval 0.01-0.017); p = 9 × 10−11.

How common The A allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 2, band 2p23.2 — between genes, 18.6 kb from PLB1.

How common each version is

AG
Korean KRGDB
A 78.9% · G 21.1%
Korean Korea4K
A 78.5% · G 21.6%
Korean Korea1K
A 77.6% · G 22.4%
Japanese ToMMo
A 76.1% · G 23.9%
Vietnamese
A 71.7% · G 28.3%
World gnomAD
A 18.2% · G 81.8%
World 1000 Genomes
A 27.6% · G 72.4%
World TOPMed
A 18.6% · G 81.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Source

Quoting this page

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Total cholesterol levels (rs11676985). MyGeneLog™. https://www.mygenelog.com/variants/rs11676985

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