Disorders of the autonomic nervous system (PheCode 337)
near UCA1-AS1 · rs11673376
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,866 African American or Afro-Caribbean cases, 114,802 African American or Afro-Caribbean controls, 14,559 European ancestry cases, 421,084 European ancestry controls, 1,135 Hispanic or Latin American cases, 57,217 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 0.0785 lower (95% confidence interval 0.057-0.1); p = 4 × 10−11.
How common The C allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 19, band 19p13.12 — between genes, 2.5 kb from UCA1-AS1.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Disorders of the autonomic nervous system (PheCode 337) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Disorders of the autonomic nervous system (PheCode 337).
T/TPublished research associates this genotype with typical/baseline likelihood of Disorders of the autonomic nervous system (PheCode 337) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs11673376
What is rs11673376?
rs11673376 is a single position in the genome, in or near the near UCA1-AS1 gene. Published research associates it with disorders of the autonomic nervous system (phecode 337). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11673376 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11673376 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Disorders of the autonomic nervous system (PheCode 337) (rs11673376). MyGeneLog™. https://www.mygenelog.com/variants/rs11673376