Sensitive

Dupuytren's disease

DUXA · rs11672517

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Dupuytren's disease compared to the general population. (GWAS Catalog, N Engl J Med 2011, PMID:21732829)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Dupuytren's disease. (GWAS Catalog, N Engl J Med 2011, PMID:21732829)

G/G Published research associates this genotype with typical/baseline likelihood of Dupuytren's disease — no copies of the reported risk allele. (GWAS Catalog, N Engl J Med 2011, PMID:21732829)

Source

Wnt signaling and Dupuytren's disease

Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M

and 7 more — show all

Franke A, Klopp N, Wichmann HE, Nürnberg P, Giele H, Ophoff RA, Wijmenga C

Dutch Dupuytren Study Group · German Dupuytren Study Group · LifeLines Cohort Study · BSSH-GODD Consortium

The New England journal of medicine · 2011 · PMID 21732829

Questions about rs11672517

What is rs11672517?

rs11672517 is a single position in the genome, in or near the DUXA gene. Published research associates it with dupuytren's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11672517 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11672517 come from?

GWAS Catalog, N Engl J Med 2011, PMID:21732829. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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