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Urea levels

ASH1L · rs116698232

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 342,286 European ancestry individuals, 6,015 African ancestry individuals, 7,336 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0516 higher (95% confidence interval 0.035-0.068); p = 1 × 10⁻⁹.

Where it sits Chromosome 1, band 1q22 — in an intron of ASH1L.

What each result means

C/C No copy of the version the research linked to Urea levels. This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to Urea levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Urea levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs116698232

What is rs116698232?

rs116698232 is a single position in the genome, in or near the ASH1L gene. Published research associates it with urea levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs116698232 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs116698232 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urea levels (rs116698232). MyGeneLog™. https://www.mygenelog.com/variants/rs116698232

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