NEXN · rs1166698
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,205,871 European ancestry individuals, 168,300 East Asian ancestry individuals, 63,553 African ancestry individuals, 23,509 Hispanic or Latin American individuals, 22,103 African American individuals, 21,791 Central Asian or South Asian ancestry individuals, 1,502 Middle Eastern ancestry individuals, 939 other admixed ancestry individuals, 602 Native American ancestry individuals, 150 Asian ancestry individuals, 339 individuals.
The effect Each copy of the A allele shifted the measure 9.37 z score higher; p = 7 × 10−21.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 1, band 1p31.1 — a missense change in NEXN.
What ClinVar records
Classification
Benign for Cardiovascular phenotype, Hypertrophic cardiomyopathy 20, Dilated cardiomyopathy 1CC; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 12 submitters), last evaluated 2026-02-04.
ClinVar record 47911 NM_144573.4(NEXN):c.733G>A (p.Gly245Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs1166698 is a single position in the genome, in or near the NEXN gene. Published research associates it with estimated glomerular filtration rate (creatinine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2022, PMID:35710981. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estimated glomerular filtration rate (creatinine) (rs1166698). MyGeneLog™. https://www.mygenelog.com/variants/rs1166698