Standard

Educational attainment

DCC · rs11664320

Where this position leads

Condition: Educational Attainment

rs11664320 Condition: Educational Attainment Educational Attainment Condition rs11664320 rs11664320 DCC

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−62, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 3,037,499 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0176 higher (95% confidence interval 0.016-0.02); p = 2 × 10−62.

How common The T allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — in an intron of DCC.

What each result means

C/C No copy of the version the research linked to Educational attainment. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Educational attainment. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11664320

What is rs11664320?

rs11664320 is a single position in the genome, in or near the DCC gene. Published research associates it with educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11664320 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs11664320 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11664320 come from?

GWAS Catalog, Nature genetics 2022, PMID:35361970. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Educational attainment (rs11664320). MyGeneLog™. https://www.mygenelog.com/variants/rs11664320

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