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Who was studied 2,780 European ancestry cases, 12,515 European ancestry controls; replicated in 3,111 Japanese ancestry cases, 1,666 Japanese ancestry controls.
The effect
Each copy of the C allele carried 1.22 times the odds of Intracranial aneurysm (95% confidence interval 1.15-1.28); p = 1 × 10−12.
How common The C allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 18, band 18q11.2 — in an intron of RBBP8-AS1.
What each result means
A/ANo copy of the version the research linked to Intracranial aneurysm. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Intracranial aneurysm. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Intracranial aneurysm. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2010 · PMID 20364137 · open access
Questions about rs11661542
What is rs11661542?
rs11661542 is a single position in the genome, in or near the RBBP8 gene. Published research associates it with intracranial aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11661542 linked to?
On MyGeneLog this position is linked to Intracranial Aneurysm. The research behind each link, and its sources, are set out on that condition page.
Does having rs11661542 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11661542 come from?
GWAS Catalog, Nat Genet 2010, PMID:20364137. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 381225223120Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity2Meta AI5Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total38Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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