Standard

Triglyceride levels

near COPZ2 · rs11656818

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 342,233 European ancestry individuals, 6,014 African ancestry individuals, 7,330 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0275 lower (95% confidence interval 0.018-0.037); p = 2 × 10⁻⁹.

Where it sits Chromosome 17, band 17q21.32 — between genes, 0.3 kb from COPZ2.

How common each version is

AC

Korean KRGDB

A 0.1% · C 99.9%

Korean Korea4K

A 0.0% · C 100.0%

Korean Korea1K

A 0.1% · C 99.9%

Japanese ToMMo

C 100.0%

Vietnamese

A 0.5% · C 99.5%

World gnomAD

A 10.2% · C 89.8%

World 1000 Genomes

A 9.3% · C 90.7%

World TOPMed

A 10.3% · C 89.7%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Triglyceride levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/C One copy of the version the research linked to Triglyceride levels. That is a smaller link than two copies.

C/C No copy of the version the research linked to Triglyceride levels. This is the starting point the study compared everyone against.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs11656818

What is rs11656818?

rs11656818 is a single position in the genome, in or near the near COPZ2 gene. Published research associates it with triglyceride levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11656818 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

Does having rs11656818 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11656818 come from?

GWAS Catalog, Nat Genet 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Triglyceride levels (rs11656818). MyGeneLog™. https://www.mygenelog.com/variants/rs11656818

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