Standard

Triglycerides

PEMT · rs11654777

Where this position leads

Condition: High Triglycerides

rs11654777 Condition: High Triglycerides High Triglycerides Condition rs11654777 rs11654777 PEMT

What the study found

Who was studied 343,992 European ancestry individuals, 111,667 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0404 higher (95% confidence interval 0.031-0.05); p = 8 × 10−17.

Where it sits Chromosome 17, band 17p11.2 — in an intron of PEMT.

What each result means

C/C No copy of the version the research linked to Triglycerides. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Triglycerides. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Triglycerides. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11654777

What is rs11654777?

rs11654777 is a single position in the genome, in or near the PEMT gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11654777 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

Does having rs11654777 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11654777 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Triglycerides (rs11654777). MyGeneLog™. https://www.mygenelog.com/variants/rs11654777

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