Standard
Pulmonary function (smoking interaction)
SOX9 · rs11654749
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of Pulmonary function (smoking interaction) — no copies of the reported risk allele.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulmonary function (smoking interaction).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulmonary function (smoking interaction) compared to the general population.
Source
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
Hancock DB,
Soler Artigas M,
Gharib SA,
Henry A,
Manichaikul A,
Ramasamy A,
Loth DW,
Imboden M,
Koch B,
McArdle WL,
Smith AV,
Smolonska J
and 78 more — show all
Sood A,
Tang W,
Wilk JB,
Zhai G,
Zhao JH,
Aschard H,
Burkart KM,
Curjuric I,
Eijgelsheim M,
Elliott P,
Gu X,
Harris TB,
Janson C,
Homuth G,
Hysi PG,
Liu JZ,
Loehr LR,
Lohman K,
Loos RJ,
Manning AK,
Marciante KD,
Obeidat M,
Postma DS,
Aldrich MC,
Brusselle GG,
Chen TH,
Eiriksdottir G,
Franceschini N,
Heinrich J,
Rotter JI,
Wijmenga C,
Williams OD,
Bentley AR,
Hofman A,
Laurie CC,
Lumley T,
Morrison AC,
Joubert BR,
Rivadeneira F,
Couper DJ,
Kritchevsky SB,
Liu Y,
Wjst M,
Wain LV,
Vonk JM,
Uitterlinden AG,
Rochat T,
Rich SS,
Psaty BM,
O'Connor GT,
North KE,
Mirel DB,
Meibohm B,
Launer LJ,
Khaw KT,
Hartikainen AL,
Hammond CJ,
Gläser S,
Marchini J,
Kraft P,
Wareham NJ,
Völzke H,
Stricker BH,
Spector TD,
Probst-Hensch NM,
Jarvis D,
Jarvelin MR,
Heckbert SR,
Gudnason V,
Boezen HM,
Barr RG,
Cassano PA,
Strachan DP,
Fornage M,
Hall IP,
Dupuis J,
Tobin MD,
London SJ
PLoS genetics · 2012 · PMID 23284291 · open access
Questions about rs11654749
What is rs11654749?
rs11654749 is a single position in the genome, in or near the SOX9 gene. Published research associates it with pulmonary function (smoking interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11654749 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11654749 come from?
GWAS Catalog, PLoS Genet 2012, PMID:23284291. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants