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Pulmonary function (smoking interaction)

SOX9 · rs11654749

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 50,047 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0 higher (95% confidence interval -0.00008-0.00018); p = 7 × 10⁻⁸.

How common The T allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 17, band 17q24.3 — in an intron of CASC17.

What each result means

G/G No copy of the version the research linked to Pulmonary function (smoking interaction). This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Pulmonary function (smoking interaction). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Pulmonary function (smoking interaction). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

Hancock DB, Soler Artigas M, Gharib SA, Henry A, Manichaikul A, Ramasamy A, Loth DW, Imboden M, Koch B, McArdle WL, Smith AV, Smolonska J

and 78 more — show all

Sood A, Tang W, Wilk JB, Zhai G, Zhao JH, Aschard H, Burkart KM, Curjuric I, Eijgelsheim M, Elliott P, Gu X, Harris TB, Janson C, Homuth G, Hysi PG, Liu JZ, Loehr LR, Lohman K, Loos RJ, Manning AK, Marciante KD, Obeidat M, Postma DS, Aldrich MC, Brusselle GG, Chen TH, Eiriksdottir G, Franceschini N, Heinrich J, Rotter JI, Wijmenga C, Williams OD, Bentley AR, Hofman A, Laurie CC, Lumley T, Morrison AC, Joubert BR, Rivadeneira F, Couper DJ, Kritchevsky SB, Liu Y, Wjst M, Wain LV, Vonk JM, Uitterlinden AG, Rochat T, Rich SS, Psaty BM, O'Connor GT, North KE, Mirel DB, Meibohm B, Launer LJ, Khaw KT, Hartikainen AL, Hammond CJ, Gläser S, Marchini J, Kraft P, Wareham NJ, Völzke H, Stricker BH, Spector TD, Probst-Hensch NM, Jarvis D, Jarvelin MR, Heckbert SR, Gudnason V, Boezen HM, Barr RG, Cassano PA, Strachan DP, Fornage M, Hall IP, Dupuis J, Tobin MD, London SJ

PLoS genetics · 2012 · PMID 23284291 · open access

Questions about rs11654749

What is rs11654749?

rs11654749 is a single position in the genome, in or near the SOX9 gene. Published research associates it with pulmonary function (smoking interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11654749 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs11654749 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11654749 come from?

GWAS Catalog, PLoS Genet 2012, PMID:23284291. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary function (smoking interaction) (rs11654749). MyGeneLog™. https://www.mygenelog.com/variants/rs11654749

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