0 91233Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others3Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,662 African American or Afro-Caribbean cases, 119,348 African American or Afro-Caribbean controls, 1,769 Hispanic or Latin American cases, 57,447 Hispanic or Latin American controls, 236 East Asian ancestry cases, 6,526 East Asian ancestry controls, 15,635 European ancestry cases, 429,252 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0841 higher (95% confidence interval 0.061-0.107); p = 3 × 10−14.
How common The A allele had a frequency of about 56% in the people studied.
Where it sits Chromosome 17, band 17q25.3 — a missense change in CARD14.
What ClinVar records
ClassificationBenign/Likely benign; association for Pityriasis rubra pilaris, Psoriasis 2; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 10 submitters), last evaluated 2026-02-04.
ClinVar record 402486NM_001366385.1(CARD14):c.2399-4A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Psoriasis vulgaris (PheCode 696.41). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Psoriasis vulgaris (PheCode 696.41). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Psoriasis vulgaris (PheCode 696.41). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs11653893
What is rs11653893?
rs11653893 is a single position in the genome, in or near the CARD14 gene. Published research associates it with psoriasis vulgaris (phecode 696.41). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11653893 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs11653893 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11653893 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91233Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others3Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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