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X-21410 levels

SLC17A3 · rs1165161

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−25, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 6,136 Finnish ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.27 higher; p = 3 × 10−25.

Where it sits Chromosome 6, band 6p22.2 — in an intron of SLC17A3.

What each result means

C/C No copy of the version the research linked to X-21410 levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to X-21410 levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to X-21410 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Yin X, Chan LS, Bose D, Jackson AU, VandeHaar P, Locke AE, Fuchsberger C, Stringham HM, Welch R, Yu K, Fernandes Silva L, Service SK
and 25 more — show all
Zhang D, Hector EC, Young E, Ganel L, Das I, Abel H, Erdos MR, Bonnycastle LL, Kuusisto J, Stitziel NO, Hall IM, Wagner GR, Kang J, Morrison J, Burant CF, Collins FS, Ripatti S, Palotie A, Freimer NB, Mohlke KL, Scott LJ, Wen X, Fauman EB, Laakso M, Boehnke M
FinnGen
Nature communications · 2022 · PMID 35347128 · open access

Questions about rs1165161

What is rs1165161?

rs1165161 is a single position in the genome, in or near the SLC17A3 gene. Published research associates it with x-21410 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1165161 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1165161 come from?

GWAS Catalog, Nature communications 2022, PMID:35347128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

X-21410 levels (rs1165161). MyGeneLog™. https://www.mygenelog.com/variants/rs1165161

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