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Who was studied 1,822 Han Chinese ancestry cases, 4,650 Han Chinese ancestry controls, 20,352 European ancestry cases, 31,358 European ancestry controls.
The effect
Each copy of the T allele carried 0.93 times the odds of Bipolar disorder (95% confidence interval 0.907-0.949); p = 9 × 10−11.
Where it sits Chromosome 16, band 16p13.2 — in an intron of GRIN2A.
What each result means
G/GNo copy of the version the research linked to Bipolar disorder. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Bipolar disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Bipolar disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs11647445 is a single position in the genome, in or near the GRIN2A gene. Published research associates it with bipolar disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11647445 linked to?
On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs11647445 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11647445 come from?
GWAS Catalog, JAMA psychiatry 2021, PMID:33263727. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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