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Haptoglobin levels

near PMFBP1 · rs11645898

What the study found

Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.468 lower (95% confidence interval 0.35-0.58); p = 2 × 10−15.

Where it sits Chromosome 16, band 16q22.2 — between genes, 18.8 kb from PMFBP1.

What each result means

C/C Two copies of the version the research linked to Haptoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Haptoglobin levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Haptoglobin levels. This is the starting point the study compared everyone against.
Source

Questions about rs11645898

What is rs11645898?

rs11645898 is a single position in the genome, in or near the near PMFBP1 gene. Published research associates it with haptoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11645898 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11645898 come from?

GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Haptoglobin levels (rs11645898). MyGeneLog™. https://www.mygenelog.com/variants/rs11645898

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