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Allergic rhinitis

RMI2 · rs11644510

Where this position leads

What the study found

Who was studied 59,762 European and unknown ancestry cases, 152,358 European and unknown ancestry controls; replicated in 60,720 European ancestry cases, 618,527 European ancestry controls.

The effect Each copy of the C allele carried 1.08 times the odds of Allergic rhinitis (95% confidence interval 1.05-1.09); p = 2 × 10⁻¹⁷.

How common The C allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 16, band 16p13.13 — between genes, 1.3 kb from CLEC16A.

What each result means

C/C Two copies of the version the research linked to Allergic rhinitis. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Allergic rhinitis. That is a smaller link than two copies.

T/T No copy of the version the research linked to Allergic rhinitis. This is the starting point the study compared everyone against.

Source

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS

and 76 more — show all

Antó JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonàs-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K

23andMe Research Team · AAGC collaborators

Nature genetics · 2018 · PMID 30013184

Questions about rs11644510

What is rs11644510?

rs11644510 is a single position in the genome, in or near the RMI2 gene. Published research associates it with allergic rhinitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11644510 linked to?

On MyGeneLog this position is linked to Allergic Rhinitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11644510 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11644510 come from?

GWAS Catalog, Nature genetics 2018, PMID:30013184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Allergic rhinitis (rs11644510). MyGeneLog™. https://www.mygenelog.com/variants/rs11644510

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