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Age-related hearing impairment

MMP2 · rs11643684

Where this position leads

Condition: Age-Related Hearing Loss

rs11643684 Condition: Age-Related Hearing Loss Age-Related Hearing Loss Condition rs11643684 rs11643684 MMP2

What the study found

Who was studied 147,997 European ancestry cases, 575,269 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0069 lower (95% confidence interval 0.0047-0.0091); p = 2 × 10−9.

How common The T allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 16, band 16q12.2 — in an intron of MMP2-AS1.

What each result means

G/G No copy of the version the research linked to Age-related hearing impairment. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Age-related hearing impairment. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Age-related hearing impairment. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11643684

What is rs11643684?

rs11643684 is a single position in the genome, in or near the MMP2 gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11643684 linked to?

On MyGeneLog this position is linked to Age-Related Hearing Loss. The research behind each link, and its sources, are set out on that condition page.

Does having rs11643684 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11643684 come from?

GWAS Catalog, American journal of human genetics 2022, PMID:35580588. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Age-related hearing impairment (rs11643684). MyGeneLog™. https://www.mygenelog.com/variants/rs11643684

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