Sensitive

Idiopathic knee osteoarthritis

SCAMP5 · rs11638576

Where this position leads

Condition: Knee Osteoarthritis

rs11638576 Condition: Knee Osteoarthritis Knee Osteoarthritis Condition rs11638576 rs11638576 SCAMP5

What the study found

Who was studied 90,888 European ancestry cases, 263,673 European ancestry controls.

The effect Each copy of the A allele carried 1.04 times the odds of Idiopathic knee osteoarthritis (95% confidence interval 1.03-1.05); p = 1 × 10−12.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 15, band 15q24.2 — inside SCAMP5.

What each result means

A/A Two copies of the version the research linked to Idiopathic knee osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Idiopathic knee osteoarthritis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Idiopathic knee osteoarthritis. This is the starting point the study compared everyone against.
Source

Questions about rs11638576

What is rs11638576?

rs11638576 is a single position in the genome, in or near the SCAMP5 gene. Published research associates it with idiopathic knee osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11638576 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11638576 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11638576 come from?

GWAS Catalog, Osteoarthritis and cartilage 2023, PMID:37247657. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Idiopathic knee osteoarthritis (rs11638576). MyGeneLog™. https://www.mygenelog.com/variants/rs11638576

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