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Chronic lymphocytic leukemia

MNS1 · rs11636802

Where this position leads

Condition: Chronic Lymphocytic Leukaemia

What the study found

Who was studied 2,179 European ancestry cases, 6,221 European ancestry controls; replicated in 1,709 European ancestry cases, 6,318 European ancestry controls.

The effect Each copy of the G allele carried 1.41 times the odds of Chronic lymphocytic leukemia; p = 2 × 10⁻¹³.

How common The G allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 15, band 15q21.3 — inside LOC105370832.

What each result means

A/A No copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, Cozen W, Monnereau A, Wang SS, Kelly RS, Lan Q, Teras LR

and 118 more — show all

Chatterjee N, Chung CC, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Armstrong BK, Cocco P, Zhang Y, Severi G, Zeleniuch-Jacquotte A, Lawrence C, Burdette L, Yuenger J, Hutchinson A, Jacobs KB, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Wang AH, Smedby KE, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Jones B, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Holly EA, Smith MT, Jackson RD, Tinker LF, Benavente Y, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Leis JF, Cunningham JM, Weinberg JB, Morrison VA, Caporaso NE, Norman AD, Linet MS, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Giles GG, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Offit K, Zelenetz A, Klein RJ, Spinelli JJ, Bertrand KA, Laden F, Giovannucci E, Kraft P, Kricker A, Turner J, Vajdic CM, Ennas MG, Ferri GM, Miligi L, Liang L, Sampson J, Crouch S, Park JH, North KE, Cox A, Snowden JA, Wright J, Carracedo A, Lopez-Otin C, Bea S, Salaverria I, Martin-Garcia D, Campo E, Fraumeni JF Jr, de Sanjose S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager SL

Nature genetics · 2013 · PMID 23770605 · open access

Questions about rs11636802

What is rs11636802?

rs11636802 is a single position in the genome, in or near the MNS1 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11636802 linked to?

On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs11636802 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11636802 come from?

GWAS Catalog, Nat Genet 2013, PMID:23770605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic lymphocytic leukemia (rs11636802). MyGeneLog™. https://www.mygenelog.com/variants/rs11636802

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