Standard

Systolic blood pressure

NRG4 · rs11636251

Where this position leads

What the study found

Who was studied 365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals; replicated in 299,024 European ancestry individuals, 17,277 individuals.

The effect Each copy of the T allele shifted the measure 0.191 mmHg higher (95% confidence interval 0.14-0.24); p = 2 × 10⁻¹².

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 15, band 15q24.2 — in an intron of NRG4.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Systolic blood pressure — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systolic blood pressure.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systolic blood pressure compared to the general population.

Source

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL

and 86 more — show all

Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, Thériault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, Sepúlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR, Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K, O'Donnell CJ, Hung AM, Edwards TL

Understanding Society Scientific Group · International Consortium for Blood Pressure · Blood Pressure-International Consortium of Exome Chip Studies · Million Veteran Program

Nature genetics · 2019 · PMID 30578418 · open access

Questions about rs11636251

What is rs11636251?

rs11636251 is a single position in the genome, in or near the NRG4 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11636251 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs11636251 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11636251 come from?

GWAS Catalog, Nat Genet 2018, PMID:30578418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants