HERC2 · rs11636232
Where this position leads
Condition: Eye Color and Pigmentation
What the study found
Who was studied 4,987 Iberian ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.854 lower (95% confidence interval 0.8-0.91); p = 3 × 10−197.
How common The T allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 15, band 15q13.1 — a synonymous change in HERC2.
What ClinVar records
Classification
Benign/Likely benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2024-11-27.
ClinVar record 1224285 NM_004667.6(HERC2):c.11967G>A (p.Gln3989=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs11636232 is a single position in the genome, in or near the HERC2 gene. Published research associates it with eye color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Eye Color and Pigmentation. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genes 2023, PMID:36672889. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Eye color (rs11636232). MyGeneLog™. https://www.mygenelog.com/variants/rs11636232