Sensitive

Coronary artery disease

NEDD4 · rs11633313

Where this position leads

Condition: Coronary Artery Disease

rs11633313 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs11633313 rs11633313 NEDD4

What the study found

Who was studied 190,493 European ancestry cases, 582,775 European ancestry controls, 6,378 Hispanic or Latin American cases, 24,270 Hispanic or Latin American controls, 1,702 African American or Afro-Caribbean cases, 59,507 African American or Afro-Caribbean controls, 29,319 East Asian ancestry cases, 183,134 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0237 higher (95% confidence interval 0.016-0.032); p = 2 × 10−9.

How common The A allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 15, band 15q21.3 — in an intron of NEDD4.

What each result means

A/A Two copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Source

Questions about rs11633313

What is rs11633313?

rs11633313 is a single position in the genome, in or near the NEDD4 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11633313 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs11633313 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11633313 come from?

GWAS Catalog, Nature medicine 2022, PMID:35915156. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary artery disease (rs11633313). MyGeneLog™. https://www.mygenelog.com/variants/rs11633313

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