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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 7,796 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.019 higher (95% confidence interval 0.015-0.023); p = 7 × 10−27.
How common The T allele had a frequency of about 60% in the people studied.
Where it sits Chromosome 1, band 1p12 — in an intron of PHGDH.
What each result means
C/CNo copy of the version the research linked to Serine levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Serine levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Serine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2014 · PMID 24816252 · open access
Questions about rs1163251
What is rs1163251?
rs1163251 is a single position in the genome, in or near the PHGDH gene. Published research associates it with serine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1163251 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1163251 come from?
GWAS Catalog, Nature genetics 2014, PMID:24816252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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