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Objective response to lithium treatment

SESTD1 · rs116323614

Where this position leads

Condition: Bipolar Disorder

rs116323614 Condition: Bipolar Disorder Bipolar Disorder Condition rs116323614 rs116323614 SESTD1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Objective response to lithium treatment compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Objective response to lithium treatment.
G/G Published research associates this genotype with typical/baseline likelihood of Objective response to lithium treatment — no copies of the reported risk allele.
Source
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK
and 39 more — show all
Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA
Members of the International Cohort Collection for Bipolar Disorder (ICCBD)
Molecular psychiatry · 2016 · PMID 26503763 · open access

Questions about rs116323614

What is rs116323614?

rs116323614 is a single position in the genome, in or near the SESTD1 gene. Published research associates it with objective response to lithium treatment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs116323614 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs116323614 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs116323614 come from?

GWAS Catalog, Mol Psychiatry 2015, PMID:26503763. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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