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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 80,823 European ancestry cases, 2,383,572 European ancestry controls.
The effect
Each copy of the T allele carried 1.04 times the odds of Aortic stenosis (95% confidence interval 1.02-1.05); p = 2 × 10−9.
How common The T allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 14, band 14q32.32 — in an intron of MARK3.
What each result means
A/ANo copy of the version the research linked to Aortic stenosis. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Aortic stenosis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Aortic stenosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41419686 · open access
Questions about rs11624343
What is rs11624343?
rs11624343 is a single position in the genome, in or near the MARK3 gene. Published research associates it with aortic stenosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11624343 linked to?
On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs11624343 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11624343 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419686. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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