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Preserved ratio impaired spirometry

RIN3 · rs11623779

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 289,782 European ancestry individuals; replicated in 5,165 European ancestry cases, 47,729 European ancestry controls.

The effect Each copy of the T allele carried 1.01 times the odds of Preserved ratio impaired spirometry (95% confidence interval 1.004-1.008); p = 2 × 10−8.

How common The T allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — in an intron of RIN3.

What each result means

C/C No copy of the version the research linked to Preserved ratio impaired spirometry. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Preserved ratio impaired spirometry. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Preserved ratio impaired spirometry. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association study of preserved ratio impaired spirometry (PRISm)
Higbee DH, Lirio A, Hamilton F, Granell R, Wyss AB, London SJ, Bartz TM, Gharib SA, Cho MH, Wan E, Silverman E, Crapo JD
and 33 more — show all
Lominchar JVT, Hansen T, Grarup N, Dantoft T, Kårhus L, Linneberg A, O'Connor GT, Dupuis J, Xu H, De Vries MM, Hu X, Rich SS, Barr RG, Manichaikul A, Wijnant SRA, Brusselle GG, Lahousse L, Li X, Hernández Cordero AI, Obeidat M, Sin DD, Harris SE, Redmond P, Taylor AM, Cox SR, Williams AT, Shrine N, John C, Guyatt AL, Hall IP, Davey Smith G, Tobin MD, Dodd JW
The European respiratory journal · 2024 · PMID 38097206 · open access

Questions about rs11623779

What is rs11623779?

rs11623779 is a single position in the genome, in or near the RIN3 gene. Published research associates it with preserved ratio impaired spirometry. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11623779 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11623779 come from?

GWAS Catalog, The European respiratory journal 2024, PMID:38097206. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Preserved ratio impaired spirometry (rs11623779). MyGeneLog™. https://www.mygenelog.com/variants/rs11623779

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