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Who was studied 1,823 European ancestry individuals; replicated in 1,836 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.284 higher (95% confidence interval 0.21-0.36); p = 8 × 10−14.
How common The G allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 14, band 14q23.3 — in an intron of FUT8.
What each result means
G/GTwo copies of the version the research linked to IgG glycosylation patterns. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to IgG glycosylation patterns. That is a smaller link than two copies.
T/TNo copy of the version the research linked to IgG glycosylation patterns. This is the starting point the study compared everyone against.
Frontiers in immunology · 2018 · PMID 29535710 · open access
Questions about rs11621680
What is rs11621680?
rs11621680 is a single position in the genome, in or near the FUT8 gene. Published research associates it with igg glycosylation patterns. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11621680 linked to?
On MyGeneLog this position is linked to IgG Glycosylation. The research behind each link, and its sources, are set out on that condition page.
Does having rs11621680 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11621680 come from?
GWAS Catalog, Front Immunol 2018, PMID:29535710. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 282392318Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity3Meta AI9Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total28Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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