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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,717 European ancestry cases, 22,924 European ancestry controls.
The effect
Each copy of the A allele carried 8.73 times the odds of End-stage renal disease in diabetes (95% confidence interval 4.13-18.45); p = 1 × 10−8.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 3, band 3p22.2 — in an intron of STAC.
What each result means
A/ATwo copies of the version the research linked to End-stage renal disease in diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to End-stage renal disease in diabetes. That is a smaller link than two copies.
C/CNo copy of the version the research linked to End-stage renal disease in diabetes. This is the starting point the study compared everyone against.
rs116216059 is a single position in the genome, in or near the STAC gene. Published research associates it with end-stage renal disease in diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs116216059 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116216059 come from?
GWAS Catalog, Diabetologia 2022, PMID:35763030. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
End-stage renal disease in diabetes (rs116216059). MyGeneLog™. https://www.mygenelog.com/variants/rs116216059