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Depression

ACVR1B · rs11612312

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs11612312 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs11612312 rs11612312 ACVR1B

What the study found

Who was studied 371,184 European ancestry cases, 978,703 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0213 lower (95% confidence interval 0.014-0.028); p = 1 × 10−9.

How common The T allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 12, band 12q13.13 — in an intron of ACVR1B.

What each result means

C/C No copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Depression. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Als TD, Kurki MI, Grove J, Voloudakis G, Therrien K, Tasanko E, Nielsen TT, Naamanka J, Veerapen K, Levey DF, Bendl J, Bybjerg-Grauholm J
and 31 more — show all
Zeng B, Demontis D, Rosengren A, Athanasiadis G, Bækved-Hansen M, Qvist P, Bragi Walters G, Thorgeirsson T, Stefánsson H, Musliner KL, Rajagopal VM, Farajzadeh L, Thirstrup J, Vilhjálmsson BJ, McGrath JJ, Mattheisen M, Meier S, Agerbo E, Stefánsson K, Nordentoft M, Werge T, Hougaard DM, Mortensen PB, Stein MB, Gelernter J, Hovatta I, Roussos P, Daly MJ, Mors O, Palotie A, Børglum AD
Nature medicine · 2023 · PMID 37464041

Questions about rs11612312

What is rs11612312?

rs11612312 is a single position in the genome, in or near the ACVR1B gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11612312 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs11612312 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11612312 come from?

GWAS Catalog, Nature medicine 2023, PMID:37464041. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs11612312). MyGeneLog™. https://www.mygenelog.com/variants/rs11612312

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