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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.105 lower (95% confidence interval 0.074-0.135); p = 3 × 10−12.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 2, band 2q37.1 — between genes, 50.1 kb from SPP2.
What each result means
A/ATwo copies of the version the research linked to Total bilirubin levels (UKB data field 30840). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Total bilirubin levels (UKB data field 30840). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Total bilirubin levels (UKB data field 30840). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs116041500
What is rs116041500?
rs116041500 is a single position in the genome, in or near the near SPP2 gene. Published research associates it with total bilirubin levels (ukb data field 30840). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs116041500 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs116041500 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116041500 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total bilirubin levels (UKB data field 30840) (rs116041500). MyGeneLog™. https://www.mygenelog.com/variants/rs116041500