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Who was studied 81,247 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, endometriosis and multiple sclerosis samples).
The effect
Each copy of the T allele shifted the measure 0.035 lower (95% confidence interval 0.023-0.047); p = 2 × 10−9.
How common The T allele had a frequency of about 79% in the people studied.
Where it sits Chromosome 10, band 10q21.2 — in an intron of ARID5B.
What each result means
C/CNo copy of the version the research linked to Rheumatoid arthritis (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Rheumatoid arthritis (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Rheumatoid arthritis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs11593907
What is rs11593907?
rs11593907 is a single position in the genome, in or near the ARID5B gene. Published research associates it with rheumatoid arthritis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11593907 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs11593907 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11593907 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91116Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others6Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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