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Risk-taking tendency (4-domain principal component model)

TMEM180 · rs11592299

Where this position leads

What the study found

Who was studied 315,894 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0184 higher (95% confidence interval 0.012-0.025); p = 7 × 10⁻⁹.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 10, band 10q24.32 — in an intron of ACTR1A.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Risk-taking tendency (4-domain principal component model) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Risk-taking tendency (4-domain principal component model).

G/G Published research associates this genotype with typical/baseline likelihood of Risk-taking tendency (4-domain principal component model) — no copies of the reported risk allele.

Source

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A

and 80 more — show all

Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP

23and Me Research Team · eQTLgen Consortium · International Cannabis Consortium · Social Science Genetic Association Consortium

Nature genetics · 2019 · PMID 30643258

Questions about rs11592299

What is rs11592299?

rs11592299 is a single position in the genome, in or near the TMEM180 gene. Published research associates it with risk-taking tendency (4-domain principal component model). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11592299 linked to?

On MyGeneLog this position is linked to Adventurousness. The research behind each link, and its sources, are set out on that condition page.

Does having rs11592299 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11592299 come from?

GWAS Catalog, Nature genetics 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Risk-taking tendency (4-domain principal component model) (rs11592299). MyGeneLog™. https://www.mygenelog.com/variants/rs11592299

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