VCAN · rs115912456
Where this position leads
Condition: Waist-to-Hip Ratio (Body Fat Distribution)
What the study found
Who was studied 55,006 British ancestry males, 61,132 British ancestry females; replicated in 112,425 British ancestry males, 133,936 British ancestry females.
The effect Each copy of the G allele shifted the measure 0.0516 lower; p = 1 × 10−21.
How common The G allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 5, band 5q14.3 — inside VCAN.
What ClinVar records
Classification
Benign/Likely benign for Vitreoretinopathy; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-02-03.
ClinVar record 354395 NM_004385.5(VCAN):c.1043-10A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs115912456 is a single position in the genome, in or near the VCAN gene. Published research associates it with body fat distribution (trunk fat ratio). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2019, PMID:30664634. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body fat distribution (trunk fat ratio) (rs115912456). MyGeneLog™. https://www.mygenelog.com/variants/rs115912456