Sensitive

Alzheimer's disease

TOMM40 · rs115908094

Where this position leads

Condition: Alzheimer's Disease Risk (APOE)

rs115908094 Condition: Alzheimer's Disease Risk (APOE) Alzheimer's Disease Risk (APOE) Condition rs115908094 rs115908094 TOMM40

What the study found

Who was studied 12,074 European, African, Admixed American, Asian or unknown ancestry cases, 15,833 European, African, Admixed American, Asian or unknown ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 5 × 10−11.

Where it sits Chromosome 19, band 19q13.32 — in an intron of TOMM40.

What each result means

C/C No copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs115908094

What is rs115908094?

rs115908094 is a single position in the genome, in or near the TOMM40 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115908094 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.

Does having rs115908094 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115908094 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (rs115908094). MyGeneLog™. https://www.mygenelog.com/variants/rs115908094

← See all variants