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Mean corpuscular hemoglobin

PLCL2 · rs115792481

Where this position leads

Conditions: Colon Polyp, Blood Cell Counts

rs115792481 Condition: Colon Polyp Colon Polyp Condition Condition: Blood Cell Counts Blood Cell Counts Condition rs115792481 rs115792481 PLCL2

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−33, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 128,028 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0829 lower (95% confidence interval 0.07-0.096); p = 5 × 10−34.

How common The T allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 3, band 3p24.3 — in an intron of PLCL2.

What each result means

G/G No copy of the version the research linked to Mean corpuscular hemoglobin. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Mean corpuscular hemoglobin. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Mean corpuscular hemoglobin. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs115792481

What is rs115792481?

rs115792481 is a single position in the genome, in or near the PLCL2 gene. Published research associates it with mean corpuscular hemoglobin. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115792481 linked to?

On MyGeneLog this position is linked to Colon Polyp, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs115792481 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115792481 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mean corpuscular hemoglobin (rs115792481). MyGeneLog™. https://www.mygenelog.com/variants/rs115792481

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