SLC30A7 · rs11578655
Where this position leads
Condition: Multiple Sclerosis
Strength of the evidence
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 14,802 European and unknown ancestry cases, 26,703 European and unknown ancestry controls; replicated in 32,627 European and unknown ancestry cases, 41,672 European and unknown ancestry controls.
The effect Each copy of the G allele carried 1.09 times the odds of Multiple sclerosis; p = 3 × 10−8.
Where it sits Chromosome 1, band 1p21.2 — in an intron of SLC30A7.
How common each version is
GT
G 5.1% · T 94.9%
G 4.2% · T 95.8%
G 5.0% · T 95.0%
G 3.8% · T 96.2%
G 4.6% · T 95.4%
G 11.4% · T 88.6%
G 9.2% · T 90.8%
G 12.0% · T 88.0%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs11578655 is a single position in the genome, in or near the SLC30A7 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Science 2019, PMID:31604244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Multiple sclerosis (rs11578655). MyGeneLog™. https://www.mygenelog.com/variants/rs11578655