0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 9,207 European ancestry cases, 953,183 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.192 lower (95% confidence interval 0.13-0.25); p = 7 × 10−11.
How common The A allele had a frequency of about 10% in the people studied.
Where it sits Chromosome 1, band 1q21.3 — in an intron of RORC.
What each result means
A/ATwo copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
Life (Basel, Switzerland) · 2026 · PMID 42355477 · open access
Questions about rs11578418
What is rs11578418?
rs11578418 is a single position in the genome, in or near the RORC gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11578418 linked to?
On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs11578418 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11578418 come from?
GWAS Catalog, Life (Basel, Switzerland) 2026, PMID:42355477. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.