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Who was studied 1,223 European ancestry cases, 4,097 European ancestry controls.
The effect
Each copy of the G allele carried 1.39 times the odds of Addison's disease (95% confidence interval 1.26–1.53); p = 5 × 10−11.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 2, band 2q33.2 — between genes, 11.5 kb from CTLA4.
What each result means
A/ANo copy of the version the research linked to Addison's disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Addison's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Addison's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33574239 · open access
Questions about rs11571303
What is rs11571303?
rs11571303 is a single position in the genome, in or near the CTLA4 gene. Published research associates it with addison's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11571303 linked to?
On MyGeneLog this position is linked to Addison's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs11571303 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11571303 come from?
GWAS Catalog, Nature communications 2021, PMID:33574239. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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