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Non-ischemic heart failure (MTAG)

MYBPC3 · rs11570058

Where this position leads

What the study found

Who was studied 11,742 European ancestry cases, 691,259 European ancestry controls (MTAG boosted by heart function-related trait samples).

The effect Each copy of the A allele shifted the measure 0.0123 higher (95% confidence interval 0.0082-0.0165); p = 7 × 10⁻⁹.

How common The A allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 11, band 11p11.2 — a synonymous change in MYBPC3.

What ClinVar records

Classification Benign for Cardiovascular phenotype, Hypertrophic cardiomyopathy, Left ventricular noncompaction 10, Hypertrophic cardiomyopathy 4, Cardiomyopathy; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 17 submitters), last evaluated 2026-02-04. ClinVar record 42793 NM_000256.3(MYBPC3):c.786C>T (p.Thr262=)

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Non-ischemic heart failure (MTAG) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Non-ischemic heart failure (MTAG).

G/G Published research associates this genotype with typical/baseline likelihood of Non-ischemic heart failure (MTAG) — no copies of the reported risk allele.

Source

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K

and 18 more — show all

Onouchi Y, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K

BioBank Japan Project

Nature communications · 2025 · PMID 41184235 · open access

Questions about rs11570058

What is rs11570058?

rs11570058 is a single position in the genome, in or near the MYBPC3 gene. Published research associates it with non-ischemic heart failure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11570058 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs11570058 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11570058 come from?

GWAS Catalog, Nature communications 2025, PMID:41184235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Non-ischemic heart failure (MTAG) (rs11570058). MyGeneLog™. https://www.mygenelog.com/variants/rs11570058

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