0 91422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot4Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 521 African ancestry cases, 20,635 African ancestry controls, 513 Admixed American ancestry cases, 10,035 Admixed American ancestry controls, 1,675 East Asian ancestry cases, 174,935 East Asian ancestry controls, 27 Middle Eastern ancestry cases, 249 Middle Eastern ancestry controls, 654 South Asian ancestry cases, 9,325 South Asian ancestry controls, 44,908 European ancestry cases, 820,112 European ancestry controls, 112 Admixed ancestry cases, 2,653 Admixed ancestry controls, 284 cases, 6,190 controls.
The effect
Each copy of the A allele shifted the measure 0.216 log odds ratio lower (95% confidence interval 0.15-0.28); p = 2 × 10−11.
What each result means
A/ATwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs115686299
What is rs115686299?
rs115686299 is a single position in the genome, in or near the near HLA-C gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs115686299 linked to?
On MyGeneLog this position is linked to Lymphocytic Thyroiditis (Hashimoto's). The research behind each link, and its sources, are set out on that condition page.
Does having rs115686299 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115686299 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot4Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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