Standard

Age-related hearing impairment

near HLA-DRA · rs115596275

Where this position leads

Condition: Age-Related Hearing Loss

rs115596275 Condition: Age-Related Hearing Loss Age-Related Hearing Loss Condition rs115596275 rs115596275 near HLA-DRA

What the study found

Who was studied 147,997 European ancestry cases, 575,269 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0244 higher (95% confidence interval 0.018-0.031); p = 3 × 10−12.

How common The C allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 7.4 kb from HLA-DRB9.

What each result means

C/C Two copies of the version the research linked to Age-related hearing impairment. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Age-related hearing impairment. That is a smaller link than two copies.
G/G No copy of the version the research linked to Age-related hearing impairment. This is the starting point the study compared everyone against.
Source

Questions about rs115596275

What is rs115596275?

rs115596275 is a single position in the genome, in or near the near HLA-DRA gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115596275 linked to?

On MyGeneLog this position is linked to Age-Related Hearing Loss. The research behind each link, and its sources, are set out on that condition page.

Does having rs115596275 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115596275 come from?

GWAS Catalog, American journal of human genetics 2022, PMID:35580588. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Age-related hearing impairment (rs115596275). MyGeneLog™. https://www.mygenelog.com/variants/rs115596275

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