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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 408,112 British individuals.
The effect
Each copy of the A allele shifted the measure 0.028 lower (95% confidence interval 0.019-0.037); p = 3 × 10−10.
How common The A allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 21, band 21q22.13 — in an intron of HLCS.
What each result means
A/ATwo copies of the version the research linked to Hematocrit. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Hematocrit. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Hematocrit. This is the starting point the study compared everyone against.
rs115593871 is a single position in the genome, in or near the HLCS gene. Published research associates it with hematocrit. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs115593871 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115593871 come from?
GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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