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Who was studied 395 European ancestry cases, 1,975 European ancestry controls; replicated in 1,243 European ancestry cases, 4,779 European ancestry controls.
The effect
Each copy of the G allele carried 3.53 times the odds of Sjögren's syndrome (95% confidence interval 3.03–4.11); p = 8 × 10−114.
How common The G allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 14.3 kb from MTCO3P1.
What each result means
A/ANo copy of the version the research linked to Sjögren's syndrome. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Sjögren's syndrome. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Sjögren's syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2013 · PMID 24097067 · open access
Questions about rs115575857
What is rs115575857?
rs115575857 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with sjögren's syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs115575857 linked to?
On MyGeneLog this position is linked to Sjögren's Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs115575857 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115575857 come from?
GWAS Catalog, Nat Genet 2013, PMID:24097067. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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