Sensitive

Alzheimer's disease (late onset)

ABCA7 · rs115550680

Where this position leads

Condition: Alzheimer's Disease

rs115550680 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs115550680 rs115550680 ABCA7

What the study found

Who was studied 1,968 African American cases, 3,928 African American controls.

The effect Each copy of the G allele carried 1.79 times the odds of Alzheimer's disease (late onset) (95% confidence interval 1.47-2.12); p = 2 × 10−9.

How common The G allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 19, band 19p13.3 — in an intron of ABCA7.

What each result means

A/A No copy of the version the research linked to Alzheimer's disease (late onset). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Alzheimer's disease (late onset). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Alzheimer's disease (late onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs115550680

What is rs115550680?

rs115550680 is a single position in the genome, in or near the ABCA7 gene. Published research associates it with alzheimer's disease (late onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115550680 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs115550680?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs115550680 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115550680 come from?

GWAS Catalog, JAMA 2013, PMID:23571587. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Alzheimer's disease (late onset) (rs115550680). MyGeneLog™. https://www.mygenelog.com/variants/rs115550680

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