Alzheimer's disease, proxy Alzheimer's disease or related dementias
BIN1 · rs11554586
0 5113Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 6,740 British ancestry clinical Alzheimer's disease cases, 47,829 British ancestry proxy cases, 295,421 British ancestry controls.
The effect
Each copy of the A allele carried 1.05 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias (95% confidence interval 1.03-1.07); p = 7 × 10−9.
How common The A allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 2, band 2q14.3 — in the 5′ untranslated region of BIN1.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024 · PMID 39129223 · open access
Questions about rs11554586
What is rs11554586?
rs11554586 is a single position in the genome, in or near the BIN1 gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11554586 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs11554586 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11554586 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2024, PMID:39129223. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5113Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs11554586). MyGeneLog™. https://www.mygenelog.com/variants/rs11554586