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Who was studied 6,189 European ancestry cases, 931,046 European ancestry controls; replicated in 280 Norwegian ancestry cases, 69,141 Norwegian ancestry controls.
The effect
Each copy of the A allele carried 1.62 times the odds of Sick sinus syndrome (95% confidence interval 1.43-1.84); p = 9 × 10−14.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 12, band 12q13.13 — a missense change in KRT8.
What ClinVar records
ClassificationBenign/Likely benign for Cirrhosis, cryptogenic; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2024-02-09.
ClinVar record 14630NM_002273.4(KRT8):c.184G>T (p.Gly62Cys)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Sick sinus syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Sick sinus syndrome. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Sick sinus syndrome. This is the starting point the study compared everyone against.
European heart journal · 2021 · PMID 33580673 · open access
Questions about rs11554495
What is rs11554495?
rs11554495 is a single position in the genome, in or near the KRT8 gene. Published research associates it with sick sinus syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11554495 linked to?
On MyGeneLog this position is linked to Sick Sinus Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs11554495 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11554495 come from?
GWAS Catalog, Eur Heart J 2021, PMID:33580673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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