Sensitive

Diverticular disease

UBL4B · rs115490395

Where this position leads

Condition: Diverticular Disease

rs115490395 Condition: Diverticular Disease Diverticular Disease Condition rs115490395 rs115490395 UBL4B

What the study found

Who was studied 27,444 British ancestry cases, 382,284 British ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0164 higher; p = 4 × 10−8.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 1, band 1p13.3 — in an intron of LINC01397.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diverticular disease compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diverticular disease.
T/T Published research associates this genotype with typical/baseline likelihood of Diverticular disease — no copies of the reported risk allele.
Source

Questions about rs115490395

What is rs115490395?

rs115490395 is a single position in the genome, in or near the UBL4B gene. Published research associates it with diverticular disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115490395 linked to?

On MyGeneLog this position is linked to Diverticular Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs115490395 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115490395 come from?

GWAS Catalog, Nat Genet 2018, PMID:30177863. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Diverticular disease (rs115490395). MyGeneLog™. https://www.mygenelog.com/variants/rs115490395

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