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Vesicoureteral reflux

near BMP5 · rs1154855

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,395 European ancestry cases, 5,366 European ancestry controls.

The effect Each copy of the T allele carried 0.71 times the odds of Vesicoureteral reflux (95% confidence interval 0.630372729762264-0.794091964607055); p = 4 × 10−9.

How common The T allele had a frequency of about 52% in the people studied.

Where it sits Chromosome 6, band 6p12.1 — between genes, 6.3 kb from BMP5.

What each result means

G/G No copy of the version the research linked to Vesicoureteral reflux. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Vesicoureteral reflux. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Vesicoureteral reflux. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux
Verbitsky M, Krithivasan P, Batourina E, Khan A, Graham SE, Marasà M, Kim H, Lim TY, Weng PL, Sánchez-Rodríguez E, Mitrotti A, Ahram DF
and 67 more — show all
Zanoni F, Fasel DA, Westland R, Sampson MG, Zhang JY, Bodria M, Kil BH, Shril S, Gesualdo L, Torri F, Scolari F, Izzi C, van Wijk JAE, Saraga M, Santoro D, Conti G, Barton DE, Dobson MG, Puri P, Furth SL, Warady BA, Pisani I, Fiaccadori E, Allegri L, Degl'Innocenti ML, Piaggio G, Alam S, Gigante M, Zaza G, Esposito P, Lin F, Simões-E-Silva AC, Brodkiewicz A, Drozdz D, Zachwieja K, Miklaszewska M, Szczepanska M, Adamczyk P, Tkaczyk M, Tomczyk D, Sikora P, Mizerska-Wasiak M, Krzemien G, Szmigielska A, Zaniew M, Lozanovski VJ, Gucev Z, Ionita-Laza I, Stanaway IB, Crosslin DR, Wong CS, Hildebrandt F, Barasch J, Kenny EE, Loos RJF, Levy B, Ghiggeri GM, Hakonarson H, Latos-Bieleńska A, Materna-Kiryluk A, Darlow JM, Tasic V, Willer C, Kiryluk K, Sanna-Cherchi S, Mendelsohn CL, Gharavi AG
Journal of the American Society of Nephrology : JASN · 2021 · PMID 33597122

Questions about rs1154855

What is rs1154855?

rs1154855 is a single position in the genome, in or near the near BMP5 gene. Published research associates it with vesicoureteral reflux. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1154855 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1154855 come from?

GWAS Catalog, Journal of the American Society of Nephrology : JASN 2021, PMID:33597122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vesicoureteral reflux (rs1154855). MyGeneLog™. https://www.mygenelog.com/variants/rs1154855

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