ACSF3 · rs11547019
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,911 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.287 higher (95% confidence interval 0.22-0.35); p = 8 × 10−19.
How common The C allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 16, band 16q24.3 — a missense change in ACSF3.
What ClinVar records
Classification
Benign for Methylmalonic acidemia, Combined malonic and methylmalonic acidemia; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-02-04.
ClinVar record 136270 NM_001243279.3(ACSF3):c.49G>C (p.Ala17Pro)
Classification
Uncertain significance for Combined malonic and methylmalonic acidemia; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2025-10-06.
ClinVar record 1977983 NM_001243279.3(ACSF3):c.49G>A (p.Ala17Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs11547019 is a single position in the genome, in or near the ACSF3 gene. Published research associates it with urine ethylmalonate levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Urine ethylmalonate levels in chronic kidney disease (rs11547019). MyGeneLog™. https://www.mygenelog.com/variants/rs11547019