THRB · rs115463265
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 790 Hispanic, European, Asian, South Asian or African American individuals.
The effect Each copy of the T allele shifted the measure 1.5 lower (95% confidence interval 1.03-1.97); p = 2 × 10−9.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 3, band 3p24.2 — in an intron of RARB.
rs115463265 is a single position in the genome, in or near the THRB gene. Published research associates it with midgestational cytokine/chemokine levels (maternal genetic effect). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genome medicine 2018, PMID:30134952. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Midgestational cytokine/chemokine levels (maternal genetic effect) (rs115463265). MyGeneLog™. https://www.mygenelog.com/variants/rs115463265